EC Number |
Inhibitors |
Structure |
---|
4.2.3.6 | (7R)-(E)-6,7-dihydrofarnesyl diphosphate |
- |
|
4.2.3.6 | (7S)-(E)-6,7-dihydrofarnesyl diphosphate |
modestly competitive |
|
4.2.3.6 | 1-[([(Z)-[(3Z)-20-oxopregn-4-en-3-ylidene]amino]oxy)acetyl]proline |
40.3% inhibition at 0.0187 mM |
|
4.2.3.6 | 10-cyclopropylidene farnesyl diphosphate |
mechanism-based inhibitor |
|
4.2.3.6 | 10-fluorofarnesyl diphosphate |
- |
|
4.2.3.6 | 2-([(Z)-[(3Z)-17-hydroxy-20-oxopregn-4-en-3-ylidene]amino]oxy)-N-[2-(4-hydroxyphenyl)ethyl]acetamide |
45% inhibition at 0.0187 mM |
|
4.2.3.6 | 3-(1H-indol-2-yl)-N-[([(Z)-[(3Z)-20-oxopregn-4-en-3-ylidene]amino]oxy)acetyl]alanine |
67.8% inhibition at 0.0187 mM |
|
4.2.3.6 | 3-phenyl-4-[2-([(Z)-[(3Z)-11,17,21-trihydroxy-20-oxopregn-4-en-3-ylidene]amino]oxy)acetamido]butanoic acid |
26.7% inhibition at 0.0187 mM |
|
4.2.3.6 | 4-[2-([(Z)-[(3Z)-17-hydroxy-20-oxopregn-4-en-3-ylidene]amino]oxy)acetamido]-3-phenylbutanoic acid |
12.2% inhibition at 0.0187 mM |
|
4.2.3.6 | benzyl triethylammonium cation |
BTAC alone does not inhibit the trichodiene synthase, 5-30 microM acts as a competitive inhibitor in the presence of 5-20 microM PPi |
|