EC Number   |
Inhibitors |
Structure |
|---|
   4.2.1.28 | 1,2-Butanediol |
- |
   |
| 4.2.1.28 | 1,2-cyclohexanediol |
- |
|
| 4.2.1.28 | 1,2-ethanediol |
weak |
|
| 4.2.1.28 | 1,3-butanediol |
- |
|
| 4.2.1.28 | 2,3-Butanediol |
competitive inhibitor, Ki: 2.08 mM |
|
| 4.2.1.28 | 2,3-Butanediol |
meso isomer strong inactivator and good substrate, Ki: 0.2 mM, same stereospecificity as in normal catalysis, D- and L-isomers competitive inhibitors, Ki: 0.55 mM and 0.59 mM, respectively |
|
| 4.2.1.28 | 2-fluoroethanol |
weak |
|
| 4.2.1.28 | 3-butene-1,2-diol |
holodiol dehydratase undergoes rapid and irreversible inactivation, the inactivation cleaves the Co-C bond of adenosylcobalamin irreversibly forming unidentified radicals and cob(II)alamin that resist oxidation even in the presence of oxygen, inactivation mechanism, overview |
|
| 4.2.1.28 | 3-butyne-1,2-diol |
holodiol dehydratase undergoes rapid and irreversible inactivation, the inactivation cleaves the Co-C bond of adenosylcobalamin irreversibly forming unidentified radicals and cob(II)alamin that resist oxidation even in the presence of oxygen, inactivation mechanism, overview |
|
| 4.2.1.28 | adenosylcobalamin |
with e-propionamide group converted to carboxylic acid, inactivation during catalytic process, analogues inhibit if added prior to coenzyme |
|
