EC Number   |
Inhibitors |
Structure |
|---|
   4.2.1.123 | 2,3-iminosqualene |
effective inhibitor, complete inhibition at 1 mM |
   |
| 4.2.1.123 | 4,4,10beta-trimethyltransdecal-3beta-ol |
25% inhibition at 40 mM |
|
| 4.2.1.123 | 4-chloromercuribenzenesulfonic acid |
86% inhibition at 5 mM |
|
| 4.2.1.123 | diethyldicarbonate |
complete inhibition at 5 mM |
|
| 4.2.1.123 | Digitonin |
solubilization of the cyclase in 8 mg/ml digitonin inactivates the enzyme, its activity can be recovered by complementation of the assay buffer with octylthioglucoside above its critical micellar concentration |
|
| 4.2.1.123 | Emulgene 911 |
solubilization of the cyclase in 1 mg/ml Emulgene 911 inactivates the enzyme |
|
| 4.2.1.123 | more |
the cyclase is not influenced by EDTA concentrations up to 0.1 M, and lodoacetate is not inhibitory at 1 and 5 mM |
|
| 4.2.1.123 | N,N-Dimethyldodecylamine-N-oxide |
effective inhibitor, complete inhibition at 1 mM |
|
| 4.2.1.123 | Ro 43-8522 |
effective inhibitor, complete inhibition at 1 mM |
|
| 4.2.1.123 | Triton X-100 |
strong inactivator |
|
