EC Number   |
Inhibitors |
Structure |
|---|
   3.4.22.7 | (2S,3S)-3-(N-[(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl]carbamoyl)oxirane-2-carboxylic acid |
i.e. E-64, complete immediate and irreversible inhibition at 10 mM after 30 min incubation |
   |
| 3.4.22.7 | E-64 |
- |
|
| 3.4.22.7 | iodoacetic acid |
- |
|
| 3.4.22.7 | more |
1,10-phenantroline and pepstatine do not affect the activity of asclepain cII; activity of asclepain cII is inhibited by cysteine proteases inhibitors like E-64, but not by any other protease inhibitors such as 1,10-phenantroline, phenylmethanesulfonyl fluoride, and pepstatine |
|
| 3.4.22.7 | NaCl |
1 M, 70% loss of activity |
|
| 3.4.22.7 | PCMB |
- |
|
| 3.4.22.7 | phenylmethylsulfonyl fluoride |
incubation with 100 mM phenylmethylsulfonyl fluoride for 30 min decreases activity to 63% of the initial value, but inhibition is partially reverted when 12 mM cysteine is added to the reaction mixture |
|
| 3.4.22.7 | Sodium tetrathionate |
- |
|
