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Results 1 - 10 of 14 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.683-[(4-[[2-([(2R,3R)-3-[benzyl(cyclohexa-1,3-dien-1-ylmethyl)carbamoyl]-3-chlorooxiran-2-yl]carbonyl)-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid partial inhibition of the enzyme Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.683-[(4-[[2-[(2E)-4-[bis(naphthalen-1-ylmethyl)amino]-4-oxobut-2-enoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.683-[(4-[[2-[4-[bis(naphthalen-1-ylmethyl)amino]-2,3-dichloro-4-oxobutanoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid the chlorohydrin form of JCP-666 may inhibit the target SENP by SN2-like displacement of the chloride by the active site cysteine Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.683-[(4-[[2-[4-[bis(naphthalen-1-ylmethyl)amino]-3-chloro-2-hydroxy-4-oxobutanoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid i.e. JCP-666 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68Gu-HCl 500 mM reduces cleavage to 60%, 1 M reduces cleavage to 0% Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68hSUMO-VS human SUMO protein modified with a vinyl sulfone reactive group after the C-terminal di-glycine, contains the full length SUMO protein fused to a reactive vinyl sulfone group, an irreversible inhibitor of SENP proteases Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68more there may be a connection between a defect in SUMO-1 conjugation to the PML protein and acute promyelocytic leukemia (ALP). Specific Ulp inhibitors can therefore have therapeutic value for ALP Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68more no inhibitory effects are observed with Triton X100 (1 M), imidazole (300 mM), reduced glutathione (20 mM), maltose (20 mM), glycerol (20% v/v), ethylene glycol (20% v/v), sucrose (20% w/v), ethanol (10% v/v) Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68more inhibitor screening, overview. No inhibition by 3-[(4-[[2-[[(2R,3R)-3-(benzylcarbamoyl)-3-chlorooxiran-2-yl]carbonyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid, i.e. JCP-667 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.68N-ethylmaleimide NEM, blocks SENP activity by acting as a general alkylating agent that modifies the active site cysteine in parasite lysates Go to the Ligand Summary Page
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