EC Number |
Inhibitors |
Structure |
---|
3.4.21.62 | (dimethylamino)-1-naphthalenesulfonyl fluoride |
100% inhibition of enzyme activity with N-trans cinnamoyl imidazole as substrate, during prolonged exposure to organic solvents the active-site fluorescent label inhibitor adopts a different binding conformation |
|
3.4.21.62 | 1,10-phenanthroline |
at 37°C and pH of 7.5, 0.1 mM inhibits prosubtilisin JB1 by 40% |
|
3.4.21.62 | 1,4-dioxane |
104fold decrease in the enzymes catalytic activity for the hydrolysis reaction of vinyl butyrate with D2O and a 50% decrease in enzyme structural dynamics. Attaching increasing amounts of PEG to the enzyme reverses some of the activity loss. Poly(ethylene)-glycolylation increases protein structural dynamics in 1,4-dioxane |
|
3.4.21.62 | 1,4-dioxane |
reduces the enzyme activity. Structural changes, flexibility, hydration, and changes of the enzyme ionization state are not responsible for the low storage stability. Possible depletion or rearrangement of water molecules around the active site, or small structural perturbations around the active site or movements of counter ions |
|
3.4.21.62 | 2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid |
- |
|
3.4.21.62 | 2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid |
- |
|
3.4.21.62 | 2,2'-[[(1-[[1-(tert-butoxycarbonyl)-L-prolyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-3,1-diyl)]diacetic acid |
- |
|
3.4.21.62 | 2-phenylethaneboronic acid |
- |
|
3.4.21.62 | 2-phenylethanesulfonic acid |
- |
|
3.4.21.62 | 3,4-dichloroisocoumarin |
- |
|