EC Number |
Inhibitors |
Structure |
---|
3.2.2.29 | 2'-fluoro-2'-deoxyuridine |
- |
|
3.2.2.29 | 2'-fluoroarabino-5-formylcytidine |
- |
|
3.2.2.29 | Ca2+ |
slight inhibition of the enzymic activity |
|
3.2.2.29 | Co2+ |
complete inhibition at 5 mM |
|
3.2.2.29 | Cu2+ |
complete inhibition at 5 mM |
|
3.2.2.29 | Mg2+ |
slight inhibition of the enzymic activity |
|
3.2.2.29 | Mn2+ |
complete inhibition at 5 mM |
|
3.2.2.29 | more |
no inhibition of TDG activity on methylated G:IU mispairs by the methyl binding domain |
|
3.2.2.29 | more |
additional mismatch located at 3' of T/G have less inhibitory effect on the thymine removal than that located at 5' of T/G. Two additional mismatches located at each side of T/G completely inhibit the excision of thymine |
|
3.2.2.29 | more |
sumoylation dramatically impairs the enzyme's base-excision activity, such that guanine-thymine activity is reduced by more than 45fold and 5-formylcytosine and 5-carboxylcytosine are excised slowly, with a reaction half-life of more than 9 min at 37°C |
|