EC Number   |
Inhibitors |
Structure |
|---|
   3.2.1.130 | (3R,4R,5R)-3-(alpha-D-glucopyranosyloxy)-4-hydroxy-5-(hydroxymethyl)piperidine |
- |
   |
| 3.2.1.130 | alpha-glucopyranosyl-(1->3)-deoxymannojirimycin |
- |
|
| 3.2.1.130 | alpha-Man-1,3-noeuromycin |
potent inhibitor |
|
| 3.2.1.130 | alpha-mannopyranosyl-(1->3)-isofagomine |
- |
|
| 3.2.1.130 | alpha-mannopyranosyl-1->3-isofagomine |
- |
|
| 3.2.1.130 | alpha-mannosyl-1,3-(2-aminodeoxymannojirimycin) |
the inhibitor binds like other iminosugar inhibitors. The poor inhibition shown by this compound is not a result of a failure to achieve the expected interaction with the general base, but rather the reduction in basicity of the endocyclic nitrogen caused by introduction of a vicinal, protonated amine at C2 |
|
| 3.2.1.130 | alpha-mannosyl-1,3-mannoimidazole |
the inhibitor binds with the imidazole headgroup distorted downwards, a result of an unfavourable interaction with a conserved active site tyrosine |
|
| 3.2.1.130 | Glucosyl alpha1-3(1-deoxy)mannojirimycin |
- |
|
| 3.2.1.130 | more |
not impaired by 1-deoxynojirimycin, no inhibition by EDTA |
|
| 3.2.1.130 | more |
unaffected by glucosidase inhibitors |
|
