EC Number   |
Inhibitors |
Structure |
|---|
   3.1.4.52 | 5'-phosphoguanylyl-(3'-5')-guanosine |
the cyclic di-GMP phosphodiesterase activity of YfgFGE and YfgFE is inhibited by the reaction product |
   |
| 3.1.4.52 | Ca2+ |
strong |
|
| 3.1.4.52 | Ca2+ |
Ca2+ ions inhibit the phosphodiesterase activity |
|
| 3.1.4.52 | Ca2+ |
complete inhibition at 10 mM |
|
| 3.1.4.52 | Ca2+ |
inhibits both YfgF GGDEF-EAL (YfgFGE) and EAL (YfgFE) domains |
|
| 3.1.4.52 | Cu2+ |
complete inhibition at 10 mM |
|
| 3.1.4.52 | GTP |
inhibition of the phosphodiesterase, reduction of tobramycin biofilm stimulation, and suppression of biofilm response, overview |
|
| 3.1.4.52 | more |
inhibition of the enzyme leads to suppression of induction of biofilm formation |
|
| 3.1.4.52 | N-(4-hydroxyphenyl)-4-(3-oxo-1,2-benzothiazol-2(3H)-yl)butanamide |
compound inhibits Pseudomonas. aeruginosa (PAO1) swarming but not swimming or biofilm formation, it does not inhibit other Pseudomonas aeruginosa phosphodiesterases, such as DipA, PvrR and PA4108 |
|
| 3.1.4.52 | Nalidixic acid |
reduction of tobramycin biofilm stimulation and suppression of biofilm response, overview |
|
