EC Number |
Inhibitors |
Structure |
---|
3.1.4.44 | Ca2+ |
inhibition above 10 mM |
|
3.1.4.44 | EDTA |
- |
|
3.1.4.44 | glycerophosphate |
- |
|
3.1.4.44 | glycerophosphoethanolamine |
blocks the hydrolysis of glycerophosphoinositol by 30% |
|
3.1.4.44 | glycerophosphoinositol 4,5-diphosphate |
blocks the hydrolysis of glycerophosphoinositol by 70% |
|
3.1.4.44 | Glycerophosphoinositol 4-phosphate |
blocks the hydrolysis of glycerophosphoinositol by 30% |
|
3.1.4.44 | glycerophosphoserine |
blocks the hydrolysis of glycerophosphoinositol by 80% |
|
3.1.4.44 | more |
GDE1 activity expressed in HEK 293T cells can be regulated by stimulation of G protein-coupled, alpha/beta-adrenergic and lysophospholipid receptors, phenylephrine reduces the GDE1 activity by 30% and lysophatidic acid by 40% compared with untreated cells |
|
3.1.4.44 | sn-glycero-3-phospho-1-D-myo-inositol |
above 3 mM |
|
3.1.4.44 | Urea |
in vivo: activity decreases in vivo (mIMCD-3 cell), measuring choline by chemiluminescence, substrate sn-glycero-3-phosphocholine. in vitro: no directl inhibition of GDPD5 activity, GPC-PDE in vitro activity is reduced by over 60% in immuno-precipitates from HEK293 cells exposed to high urea concentration. |
|