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Results 1 - 10 of 16 > >>
EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.322-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A12B4C3 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.322-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione i.e. A12B4C3, a potent, noncompetitive inhibitor of the phosphatase activity of human polynucleotide kinase/phosphatase in vitro. The inhibitor can form a ternary complex with PNKP and a DNA substrate, the inhibitor does not prevent DNA from binding to the phosphatase DNA binding site, but disrupts the secondary structure of PNKP, interaction between Trp402 of PNKP and the inhibitor. A12B4C3 sensitizes A549 human lung cancer cells to the topoisomerase I poison, camptothecin, but not the topoisomerase II poison, etoposide, in a manner similar to small interferingRNAagainst PNKP Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.322-(hydroxy(3,4,5-trimethoxyphenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A6B4C3 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.322-(hydroxy(phenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A1B4C3 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.322-(hydroxy(thiophen-2-yl)methyl)-6-methyl-1-(phenylamino)-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A39B1C2 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.32diphosphate no effect on 3'-phosphatase, inhibition of 5'-hydroxyl kinase Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.32EDTA - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.32heparin - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.32heparin heparin exhibits an IC50 of 0.16 mg/ml Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.32more optimization of a rapid high-throughput screening method for detection of DNA 3'-phosphatases and their inhibitors, overview Go to the Ligand Summary Page
Results 1 - 10 of 16 > >>