EC Number |
Inhibitors |
Structure |
---|
3.1.11.1 | 5'-thiophosphorylated oligonucleotide |
- |
|
3.1.11.1 | camptothecin |
on exposure to camptothecin, depletion of EXO1 in CtIP-deficient cells increases the frequency of DNA-PK-dependent radial chromosome formation |
|
3.1.11.1 | EDTA |
activity 88% reduced in the presence of Mg2+ |
|
3.1.11.1 | endonuclease CtIP |
inhibitory effect of CtIP on EXO1 activity using either a radiolabelled DNA oligonucleotide substrate or a linearized plasmid both containing 3'-overhangs |
|
3.1.11.1 | fullerene-oligonucleotide conjugate |
increasing the amount of cDNA template reduces the inhibitory effect |
|
3.1.11.1 | more |
hydroxyurea induces degradation of Exo1b via polyubiquitinylation |
|
3.1.11.1 | more |
Escherichia coli RecQ inhibits Exo1, most likely by blocking Exo1 access to the ends of DNA |
|
3.1.11.1 | more |
3' G4 telomeric tails inhibit Flap cleavage by human exonuclease 1, but not by human endonuclease 1 |
|
3.1.11.1 | more |
7-kDa DNA-binding proteins are capable of significantly inhibiting the excision and enhancing the extension of matched template primers by the polymerase. The proteins do not protect single-stranded DNA from cleavage by polB1. The 7-kDa proteins do not affect the proofreading ability of polB1 and are not inhibitory to the excision of mismatched primers by the polymerase. The dNTP concentrations required for the effective inhibition of the 3'-5' exonuclease activity of polB1 are lowered from 1 mM in the absence of the 7-kDa proteins to 50 M in the presence of the proteins at 65 °C |
|
3.1.11.1 | NTP |
the strong 3'-5' exonuclease activity of polB1 is inhibited by 50% in the presence of 0.002 mM dNTPs, but remains measurable at up to 0.6 mM dNTPs |
|