EC Number |
Inhibitors |
Structure |
---|
3.1.1.98 | 2-[(2,3-dihydro-4H-1,4-benzoxazine-4-carbonyl)oxy]-7-[(6-phenoxypyridin-3-yl)methyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-(4-chlorobenzoyl)-2-[(2,3-dihydro-4H-1,4-benzoxazine-4-carbonyl)oxy]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-(4-chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 2,3-dihydro-4Hbenzo[b][1,4]oxazine-4-carboxylate |
i.e. ABC99, selective irreversible inhibitor. The optimized -hydroxyhydantoin carbamate inhibitor preserves Wnt-mediated cell signaling in the presence of NOTUM and is also converted into an ABPP probe for visualizing NOTUM in native biological systems |
|
3.1.1.98 | 7-[(2-chlorophenyl)methyl]-2-([4-(4-methoxyphenyl)piperazine-1-carbonyl]oxy)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-[(3-chlorophenyl)methyl]-2-([4-(4-methoxyphenyl)piperazine-1-carbonyl]oxy)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-[(4-bromophenyl)methyl]-2-[[4-(4-methoxyphenyl)piperazine-1-carbonyl]oxy]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-[(4-chlorophenyl)methyl]-2-([4-(4-methoxyphenyl)piperazine-1-carbonyl]oxy)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
- |
|
3.1.1.98 | 7-[(4-chlorophenyl)methyl]-2-[(2,3-dihydro-4H-1,4-benzoxazine-4-carbonyl)oxy]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
the optimized N-hydroxyhydantoin carbamate inhibitor preserves Wnt-mediated cell signaling in the presence of NOTUM and is also converted into an activity-based protein profiling (ABPP) probe for visualizing NOTUM in native biological systems. NOTUM inhibitors have potential for treating degenerative diseases |
|
3.1.1.98 | Phenylmethanesulfonylfluoride |
strong inhibition of 4-nitrophenylacetate hydrolysis |
|
3.1.1.98 | Triton X-100 |
strong inhibition of 4-nitrophenylacetate hydrolysis |
|