EC Number   |
Inhibitors |
Structure |
|---|
    3.1.1.23 | (2R,9Z)-octadec-9-ene-1,2-diamine dihydrochloride |
inhibits by 42.2% |
   |
| 3.1.1.23 | (2S)-6-[4-(hexyloxy)phenyl]hexane-1,2-diamine |
exhibits weak inhibitory activity (25.9%) |
|
| 3.1.1.23 | (2S,9Z)-octadec-9-ene-1,2-diamine |
selectively inhibits MGL by 49.9%. The presence of a long monounsaturated chain corresponding to oleic acid is a key requirement for the selective inhibition of MGL |
|
| 3.1.1.23 | (3R)-1-(3,4-dimethylphenyl)-5-oxo-N-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]pyrrolidine-3-carboxamide |
51.85% residual activity at 0.1 mM |
|
| 3.1.1.23 | (3R)-N-(3,5-dimethylphenyl)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxamide |
18.61% residual activity at 0.1 mM |
|
| 3.1.1.23 | (3S)-3-[1(R)-(biphenylacetyloxy)-ethyl]-azetidin-2-one |
16% inhibition, with 0.1 mM of inhibitor, at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0 |
|
| 3.1.1.23 | (3S)-N-(1,3-benzodioxol-4-ylmethyl)-1-[4-[(2-chlorobenzyl)oxy]phenyl]-5-oxopyrrolidine-3-carboxamide |
51.09% residual activity at 0.1 mM |
|
| 3.1.1.23 | (4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone |
- |
|
| 3.1.1.23 | (4-amidinophenyl) methanesulfonyl fluoride |
i.e. APMSF, inhibits at 0.5 mM |
|
| 3.1.1.23 | (4-[4-chlorobenzoyl]piperidin-1-yl)(4-methoxyphenyl)-methanone |
- |
|
