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EC Number Inhibitors Commentary Structure
Display the reaction diagram Show all sequences 2.7.99.B12-[(3,5-dibromo-4-methylphenyl)amino]-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylidene]acetohydrazide the Lig III inhibitor L67 leads to a 5fold increase in Ap4A, suggesting that Lig III may synthesize Ap4A in vivo when prevented from associating with DNA even in the absence of DNA damage Go to the Ligand Summary Page
Display the reaction diagram Show all sequences 2.7.99.B1DNA the enzyme activity is inhibited by DNA-binding Go to the Ligand Summary Page
Display the reaction diagram Show all sequences 2.7.99.B1more the Lig I-specific inhibitor L82, which prevents DNA-binding but not adenylation activity, causes only a slight, 1.3fold increase in the level of Ap4A in AA8 cells treated for 18 h Go to the Ligand Summary Page
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