EC Number |
Inhibitors |
Structure |
---|
2.7.8.35 | CPZEN-45 |
a caprazamycin derivative, CPZEN-45 shows excellent antitubercular activity against not only drug-sensitive strains but also some multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis strains |
|
2.7.8.35 | DMSO |
50% inhibition at 10% v/v, no inhibition at 2.86% v/v |
|
2.7.8.35 | more |
synthesis and evaluation of a series of capuramycin analogues as WecA enzyme inhibitors. No inhibition by capuramycin, UT-01309, and SQ641 |
|
2.7.8.35 | more |
poor inhibition by caprazamycin B |
|
2.7.8.35 | Rifampin |
the sensitivity of wild-type mc2155 strain against rifampin is enhanced in the presence of low concentrations of tunicamycin, a natural WecA inhibitor. An enzyme knockdown mutant strain also shows increased sensitivity to rifampin |
|
2.7.8.35 | tunicamycin |
complete inhibition at 0.02 mg/ml, 36% at 20 ng/ml |
|
2.7.8.35 | tunicamycin |
- |
|
2.7.8.35 | UT-01320 |
complete inhibition at 0.02 mg/ml, 42% at 20 ng/ml |
|
2.7.8.35 | UT-01320 |
a selective WecA inhibitor that kills both replicating and non-replicating Mycobacterium tuberculosis cells at 0.0015-0.00258 mg/ml , respectively |
|
2.7.8.35 | UT-01320 |
- |
|