EC Number |
Inhibitors |
Structure |
---|
2.7.7.3 | (1S,2S)-N-(3,4-dichlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide |
- |
|
2.7.7.3 | (1S,2S)-N-(3-chlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide |
- |
|
2.7.7.3 | (2'R)-1-methyl-N4'-[3-(trifluoromethyl)phenyl]-1,2-dihydro-5'H-spiro[indole-3,2'-[1,3,5]triazine]-4',6'-diamine |
identified by virtual screening. Compound directly binds and blocks access of substrates to the active site. The trifluoromethyl group of the ligand is oriented inside the protein molecule. One of the nitrogen atoms of the ligand forms contacts with Gly8 and Ser9. The NH2 interacts with the guanidine group of Arg90 |
|
2.7.7.3 | (2S)-2-(3-chlorophenyl)-2-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]ethyl carbamate |
- |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile |
- |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile |
lead compound as selective, small molecule inhibitor, displays modest cellular potency against the efflux-deficient Escherichia coli DeltatolC mutant strain |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile |
lead compound as selective, small molecule inhibitor |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile |
lead compound as selective, small molecule inhibitor, displays modest cellular potency against the efflux-deficient Escherichia coli DeltatolC mutant strain |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile |
lead compound as selective, small molecule inhibitor |
|
2.7.7.3 | (3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile |
- |
|