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Results 1 - 10 of 20 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95Adenylyl imidodiphosphate - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95Gentamicin 1a with neomycin as substrate, no inhibition in E. coli strain JR66/W677 or Pseudomonas aeruginosa strain Ps49 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95kanamycin substrate inhibition at 2 mM Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95more not inhibitory: guanylyl imidodiphosphate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95more identification os specific inhibitors of APHs that can restore bacterial susceptibility to aminoglycosides, screening of the Zinc database for search for allosteric inhibitors that bind to small cavities of the protein and block the enzyme function by perturbing its dynamics, docking study usig the crystal structure of the enzyme (PDB ID 1L8T) with removed aminoglycoside substrate, overview. The two interactions with side chain of Arg211 and backbones of Leu209 and Gly210 are shown to play an essential role in the inhibition of APH. No inhibition by ZINC20785546, ZINC20737652, ZINC40455179, ZINC6751595, ZINC14746000, ZINC36589946, and ZINC22357542 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95tobramycin - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95ZINC05277506 - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95ZINC08981682 7% inhibition at 0.5 mM Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95ZINC1143187 12% inhibition at 0.5 mM Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.95ZINC12636347 37% inhibition at 0.5 mM Go to the Ligand Summary Page
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