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Results 1 - 10 of 16 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.1602'-fluoroarabinose replacing the NMN ribose of NAD+ with 2'-fluoroarabinose (thereby eliminating the ribose O2'' nucleophile) results in durable trapping of RNA-2'-phospho-ADP-fluoroarabinose as a dead-end product of step 1. High utilization of ara-2''F-NAD+ as a substrate by Clostridium thermocellum Tpt1 does indeed results in trapping of the step 1 reaction product Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.1602'-fluoroarabinose replacing the NMN ribose of NAD+ with 2'-fluoroarabinose (thereby eliminating the ribose O2'' nucleophile) results in durable trapping of RNA-2'-phospho-ADP-fluoroarabinose as a dead-end product of step 1. High utilization of ara-2''F-NAD+ as a substrate by Runella slithyformis Tpt1 does indeed results in trapping of the step 1 reaction product Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.1602'-fluoroarabinose replacing the NMN ribose of NAD+ with 2'-fluoroarabinose (thereby eliminating the ribose O2''-nucleophile) results in durable trapping of RNA-2'-phospho-ADP-fluoroarabinose as a dead-end product of step 1. Low to moderate utilization of ara-2''F-NAD+ as a substrate by Chaetomium thermophilum Tpt1 results in partial trapping of the step 1 reaction product Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160ApGpApUpUpUpApC oligonucleotide, which lacks secondary structure and has no terminal phosphate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160ara-2''F-NAD+ human Tpt1 effects no detectable reaction of the 2'-phosphate RNA substrate in the presence of 0.05 mM ara-2''F-NAD+ Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160ara-2''F-NAD+ Chaetomium Tpt1 forms the dead-end product in the presence of 0.05 mM ara-2''F-NAD+, though the extent of substrate conversion is low Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160arabinose-2'-phosphate replacement of the RNA ribose-2'-phosphate nucleotide with arabinose-2'-phosphate selectively slows step 2 of the reaction pathway and results in the transient accumulation of high levels of the reaction intermediate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160EDTA inhibition of reaction by molar exess of EDTA over Mg2+ Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160EDTA - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.160Formamide - Go to the Ligand Summary Page
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