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Results 1 - 4 of 4
EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.150apilimod an inhibitor of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve, and potent inhibitor of SARS-CoV-2 strain 2019-nCoV/USA-WA1/2020. The compound prevents cytoplasmic entry of MeGFP-tagged vesicular stomatitis virus (VSV)-ebolavirus (EBOV) construct VSV-MeGFP-ZEBOV, inhibition of VSV mutant entry, overview. The virus particles are able to enter functional endosomes in presence of apilimod; HY-14644, apilimod inhibits enzyme PIKfyve and infection of SARS-CoV-2 virus. The IC50 of apilimod in experiments with authentic virus is remarkably similar to (or even more potent than) that obtained with chimeric VSV-SARS-CoV-2 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.150vacuolin-1 an inhibitor of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve. The compound prevents cytoplasmic entry of MeGFP-tagged vesicular stomatitis virus (VSV)-ebolavirus (EBOV) construct VSV-MeGFP-ZEBOV, inhibition of VSV mutant entry, overview; vacuolin-1 inhibits enzyme PIKfyve Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.150YM201636 a selective PIKfyve inhibitor Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.150YM201636 a selective FAB1/PIKfyve inhibitor Go to the Ligand Summary Page
Results 1 - 4 of 4