EC Number |
Inhibitors |
Structure |
---|
2.7.1.11 | (-)-Hydroxycitrate |
- |
|
2.7.1.11 | (NH4)2SO4 |
inhibits above 50 mM |
|
2.7.1.11 | 1,3-diphosphoglycerate |
0.385 mM and 0.005 mM, 50% inhibition of PFK I and PFK II respectively, phosphate relieves from inhibition |
|
2.7.1.11 | 2',3'-dialdehyde ATP |
irreversibly modifies a single lysine residue in the ATP-inhibitory site, thereby locking PFK in a permanantly inhibited state without affecting the integrity of the active site |
|
2.7.1.11 | 2,3-diphosphoglycerate |
- |
|
2.7.1.11 | 2-oxoglutarate |
brain PFK, not heart PFK |
|
2.7.1.11 | 2-oxoglutarate |
2 mM, 92% inhibition |
|
2.7.1.11 | 2-oxoglutarate |
competitive inhibition |
|
2.7.1.11 | 2-phosphoglycerate |
2 mM and 3.2 mM, 50% inhibition of cytosolic PFK at pH 8.0 and PH 7.2, respectively, 0.5 mM and 0.4 mM, 50% inhibition of plastid PFK at pH 8.0 and pH 7.2, respectively |
|
2.7.1.11 | 2-phosphoglycerate |
1.3 mM, 50% inhibition of cytosolic PFK, no inhibition in the presence of 5 or 25 mM phosphate |
|