EC Number   |
Inhibitors |
Structure |
|---|
    2.5.1.96 | (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol |
i.e. BPH-651, forms two crystal structures in complex with the enzyme. In both, the quinuclidine headgroup binds in the allylic S1 site with the side chain in S2, but in the presence of diphosphate and Mg2+, the quinuclidine's cationic center interacts with diphosphate and three Mg2+, mimicking a transition state involved in diphosphate ionization |
   |
| 2.5.1.96 | (S)-1-phosphono-4-(3-phenoxyphenyl)butylsulfonic acid |
far more active than (R)-compound both in vitro an in cells |
|
| 2.5.1.96 | ([[(E)-[[(3E)-4,8-dimethylnona-3,7-dien-1-yl](methyl)iminio]methyl]amino]methyl)(phosphonomethyl)phosphinate |
competitive inhibitor |
|
| 2.5.1.96 | 1-phosphono-4-[3-(3,4-difluorophenoxy)phenyl]butylsulfonic acid |
- |
|
| 2.5.1.96 | 1-phosphono-4-[3-(3-fluorophenoxy)phenyl]butylsulfonic acid |
- |
|
| 2.5.1.96 | 1-phosphono-4-[3-(4-fluorophenoxy)phenyl]butylsulfonic acid |
- |
|
| 2.5.1.96 | 1-phosphono-4-[3-(4-propylphenoxy)phenyl]butylsulfonic acid |
potent inhibitor in cell-based assay |
|
| 2.5.1.96 | 2-(4-phenoxyphenoxy)ethyl thiocyanate |
i.e. WC-9, binds to the S2 site with its -SCN group surrounded by four hydrogen bond donors |
|
| 2.5.1.96 | 4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid |
i.e. BPH-652 |
|
| 2.5.1.96 | 4-(4'-butylbiphenyl-4-yl)-1-phosphonobutane-1-sulfonic acid |
i.e. BPH-698 |
|
