EC Number   |
Inhibitors |
Structure |
|---|
    2.5.1.56 | 5-(carboxyamino)-3,5-dideoxy-2-O-phosphono-D-erythro-L-manno-nononic acid |
residues Glu25, Gln55, Asn74, Thr110, Phe112, Lys129, Asn184, Tyr186, Ser213, His215, Glu234, Phe288, and Arg314 amino acids are in close proximity and have essential interactions with the ligand |
   |
| 2.5.1.56 | 5-acetamido-4,6,7,8,9-pentahydroxy-2-phosphorylnonanoic acid ditriethylammonium salt |
4.5/1 mixture of 2S-inhibitor/2R-inhibitor, competitive inhibitor against phosphoenolpyruvate |
|
| 2.5.1.56 | AgNO3 |
1 mM, 61% inhibition |
|
| 2.5.1.56 | Co2+ |
stabilizes at low and inhibits at higher concentrations |
|
| 2.5.1.56 | Cu2+ |
1 mM CuCl2, 29% inhibition |
|
| 2.5.1.56 | Cu2+ |
10 mM CuCl2, 90% inhibition |
|
| 2.5.1.56 | EDTA |
10 mM, complete inhibition |
|
| 2.5.1.56 | EDTA |
1 or 10 mM, 97% inhibition |
|
| 2.5.1.56 | EDTA |
slightly inhibitory at 1 mM |
|
| 2.5.1.56 | ethyl 3-benzoyl-2,7-dimethyl indolizine-1-carboxylate |
inhibitor identified by molecular modeling. The compound shows important polar interactions with the Mn2+ ion, as well as with the Gln55, Asn184, and Arg314 residues |
|
