EC Number |
Inhibitors |
Structure |
---|
2.5.1.55 | (Z,E)-D-Glucophosphoenolpyruvate |
and its carboxylic ester derivatives |
|
2.5.1.55 | 1,10-phenanthroline |
- |
|
2.5.1.55 | 1,10-phenanthroline |
IC50: 0.0293 mM |
|
2.5.1.55 | 1,10-phenanthroline |
inhibits wild-type enzyme, no inhibition of mutant enzyme C11N |
|
2.5.1.55 | 1-carboxyheptane-1,7-diyl bis(phosphate) |
- |
|
2.5.1.55 | 1-[carboxy[(phosphonooxy)methyl]amino]-1-deoxy-6-O-phosphono-D-mannitol |
i.e. BPH1, the phosphate group of BPH1 interacts with Lys133 and Arg163, while the carboxylate group of BPH1 interacts with Lys50, Lys55, and His197. Inhibitor shows the highest affinity among the inhibitors tested |
|
2.5.1.55 | 2,6-Anhydro-3-deoxy-2beta-phosphonylmethyl-8-phosphate-D-glycero-D-talo-octonate |
most potent inhibitor |
|
2.5.1.55 | 2,6-pyridine dicarboxylic acid |
IC50: 0.0422 |
|
2.5.1.55 | 2,8-bis(phosphonooxy)octanoic acid |
i.e. BPH2, the phosphate group of BPH2 interacts with Lys133 and Arg163, while the carboxylate group of BPH2 interacts with Lys55, and His197 |
|
2.5.1.55 | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[(1R,2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]oxy]-4H-chromen-4-one |
i.e. hyperin, structure analysis, and enzyme interaction study, binding structure, overview |
|