EC Number |
Inhibitors |
Structure |
---|
2.5.1.26 | (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide |
- |
|
2.5.1.26 | 2,4-dinitrofluorobenzene |
1 mM, 2% activity |
|
2.5.1.26 | 2-oxo-3-(phosphonooxy)propyl hexadecanoate |
inhibitory above 0.1 mM |
|
2.5.1.26 | 3-(2,6-difluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide |
the inhibitor show higher binding affinity but retains the binding mode observed for (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide with the second fluorine atom likely enhancing the hydrophobic interactions with the aliphatic residues surrounding the substrate tunnel |
|
2.5.1.26 | 3-Bromo-2-oxoheptadecyl phosphate |
- |
|
2.5.1.26 | acyldihydroxyacetone phosphate |
high concentration, substrate inhibition |
|
2.5.1.26 | fatty acids |
competitive to fatty alcohols |
|
2.5.1.26 | fatty acids |
- |
|
2.5.1.26 | hexadecanol |
inhibitory above 0.3 mM |
|
2.5.1.26 | Mg2+ |
5 mM, 70% activity |
|