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Results 1 - 9 of 9
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27As3+ As3+ can bind to the PHD/RING finger domain of FANCL in vitro and in cells. This binding leads to compromised ubiquitination of FANCD2 in cells and diminishes recruitment of FANCD2 to chromatin and DNA damage sites induced by 4,5',8-trimethylpsoralen plus UVA irradiation Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27DTPA treatment leads to inactivation Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27EDTA treatment leads to inactivation Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27MLN4924 Nedd8 activating enzyme (NAE1) inhibitor, interferes with the activation of all cullin E3-ligases Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27more E3 ubiquitin ligase activity of isoform RBCK1 is inhibited by interaction with splice variant RBCK2 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27more binding of the RAPTA compounds, i.e. Ru(h6-arene)(1,3,5-triaza-7-phosphaadamantane)Cl2, to the BRCA1 protein results in a release of Zn2+ ions in a dose- and time-dependent manner, as well as thermal alteration of ruthenated-BRCA1 proteins. The preferential binding sites of the RAPTA complexes on the BRCA1 zinc finger RING domain are at a short peptide stretch, Cys24-Lys25-Phe26-Cys27-Met28-Leu29 and Lys35 (residues 44-49 and 55 on full length BRCA1). Binding results in inactivation of the RING heterodimer BRCA1/BARD1-mediated E3 ubiquitin ligase function Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27RAPTA-C - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27RAPTA-EA1 the IC50 value for inactivation of E3 ubiquitin ligase activity by RAPTA-EA1 is markedly lower than the corresponding values for RAPTA-C, RAPTA-T and cisplatin Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.27RAPTA-T - Go to the Ligand Summary Page
Results 1 - 9 of 9
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