EC Number   |
Inhibitors |
Structure |
|---|
    2.3.1.94 | (3R,5R)-diphenyl 6-(3,5-dihydroxy-6-phenylhexanoylamino)hexylphosphonate |
phosphonate ester, close structural homolog of substrates known to undergo macrocyclization and hydrolysis. The ester effectively inhibits the enzyme, but does not lead to co-complex structures. Pretreatment of recombinant thioesterase, residues15-283, with inhibitor for 18 h abolishes enzymatic activity for hydrolysis of the N-acetyl-cysteamine thioester of 3-hydroxyheptanoate |
   |
| 2.3.1.94 | (3S,5R)-diphenyl 6-(3,5-dihydroxy-6-phenylhexanoylamino)hexylphosphonate |
phosphonate ester, close structural homolog of substrates known to undergo macrocyclization and hydrolysis. The ester effectively inhibits the enzyme, but does not lead to co-complex structures. Pretreatment of recombinant thioesterase, residues15-283, with inhibitor for 18 h abolishes enzymatic activity for hydrolysis of the N-acetyl-cysteamine thioester of 3-hydroxyheptanoate |
|
| 2.3.1.94 | prop-2-en-1-ylphosphonic acid |
88% inhibition |
|
| 2.3.1.94 | Tetrahydrocerulenin |
- |
|
