EC Number   |
Inhibitors |
Structure |
|---|
    2.3.1.169 | 1,10-phenanthroline |
1 mM, complete inhibition. 1,10-Phenanthroline additionally has inhibitory effects on growth of Peptoclostridium difficile |
   |
| 2.3.1.169 | 2,2-dipyridyl |
1 mM, complete inhibition. 2,2-Dipyridyl additionally has inhibitory effects on growth of Peptoclostridium difficile |
|
| 2.3.1.169 | 5,5'dithiobis-(2-nitrobenzoic acid) |
inhibits the acetyl-CoA/CO exchange reaction |
|
| 2.3.1.169 | CN- |
inhibitor on the CoA/acetyl-CoA exchange, 98% inhibition at 1.2 mM |
|
| 2.3.1.169 | CO |
non-competitive inhibitor on the CoA/acetyl-CoA exchange, the Ni-Fe-C-center appears to be the inhibitor site for CO |
|
| 2.3.1.169 | CO |
inhibits the methyl group transfer reaction and synthesis of acetyl-CoA |
|
| 2.3.1.169 | CO |
the complete alpha2beta2 enzyme exhibits strong cooperative inhibition, isolated alpha is weakly inhibited, apparently by a single CO with Ki = 1.5 mM. Absence of strong cooperative inhibition of CO in mutant enzymes A265M and AA110C |
|
| 2.3.1.169 | CO2 |
inhibitor on the CoA/acetyl-CoA exchange |
|
| 2.3.1.169 | CoA |
at concentration above 10 mM, 50% inhibition of acetyl-CoA synthesis from methyl iodide at 15 mM |
|
| 2.3.1.169 | Cu2+ |
- |
|
