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Results 1 - 10 of 57 > >>
EC Number Inhibitors Commentary Structure
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.11-(3-chloro-2-methylphenyl)-3-(2-hydroxy-5-nitrophenyl)urea inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.11-(5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.11-(5-hydroxynaphthalen-1-yl)-3-(2-methyl-5-nitrophenyl)urea inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.12-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)oxy]-N-[1-(4-ethyl-6-hydroxypyrimidin-2-yl)-4-(furan-2-yl)-1H-pyrrol-2-yl]acetamide - Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.13-(2,4-dichlorophenoxy)-N-[3-(furan-2-yl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]propanamide - Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.13-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride analog of thiamine, almost completely suppresses transketolase activity in blood, spleen, and tumor cells, but has little effect on activity of the other thiamine-utilizing enzymes alpha-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.13-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride analog of thiamine, potent transketolase inhibitor but suffers from poor pharmacokinetics due to high clearance and Cmax linked toxicity. Efficient way of improving the pharmacokinetic profile is to prepare oxidized prodrugs which are slowly reduced in vivo yielding longer, sustained blood levels of the drug Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.13-formylbenzoic acid substrate inhibition Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.14'-methylamino-thiamine diphosphate cofactor analogue Go to the Ligand Summary Page
Show all pathways known for 2.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 2.2.1.1ADP - Go to the Ligand Summary Page
Results 1 - 10 of 57 > >>