EC Number   |
Inhibitors |
Structure |
|---|
   2.1.2.9 | 10-Formylaminopterin |
0.01 mM: 38% inhibition, 0.1 mM: 62% inhibition, competitive |
   |
| 2.1.2.9 | 10-formylpteroylglutamic acid |
0.1 mM: 31% inhibition, 1 mM: 52% inhibition, competitive |
|
| 2.1.2.9 | 5,10-methylenetetrahydrofolate |
- |
|
| 2.1.2.9 | 5-formyltetrahydrofolate |
competitive inhibition |
|
| 2.1.2.9 | 5-methyltetrahydrofolate |
most effective, non-competitive inhibitor |
|
| 2.1.2.9 | aminopterin |
1 mM: 26% inhibition, competitive inhibition |
|
| 2.1.2.9 | methotrexate |
0.01 mM: 30% inhibition, 0.1 mM, 52% inhibition, competitive |
|
| 2.1.2.9 | more |
inhibition studies, not inhibited by trimethoprim; not inhibited by folic acid |
|
| 2.1.2.9 | more |
not inhibited by folic acid; not inhibited by pteroic acid, aminopterin, methionyl-tRNAmMet and uncharged tRNAmMet |
|
| 2.1.2.9 | more |
E. coli A19 enzyme is not inhibited by uncharged tRNAmMet and tRNAfMet from E. coli K12 or Streptococcus faecalis |
|
