EC Number   |
Inhibitors |
Structure |
|---|
   2.1.2.8 | 10-methyl-5,8-dideazatetrahydrofolate |
competitive inhibitor with respect to tetrahydrofolate |
   |
| 2.1.2.8 | 5,5'-dithiobis(2-nitrobenzoic acid) |
complete loss of activity, second-order kinetics, inactivation is reversed by dithiothreitol, inactivation involves the modification of one thiol group per mol of dimeric enzyme |
|
| 2.1.2.8 | 5-deazatetrahydrofolate |
competitive inhibitor with respect to tetrahydrofolate |
|
| 2.1.2.8 | 5-deazatetrahydrofolate |
1 mM, 54% inhibition |
|
| 2.1.2.8 | 5-Fluoro-2'-deoxycytidine 5'-monophosphate |
competitive inhibitor with respect to dCMP, not mechanism-based inhibitor |
|
| 2.1.2.8 | 5-fluorodeoxyuridylate |
inactivates by formation of a covalent complex containing enzyme, inhibitor and methylenetetrahydrofolate in a time-dependent manner, 1 mol 5-fluoro-dUMP per enzyme monomer, no substantial inhibition of wild-type enzyme in vivo, inhibition mechanism |
|
| 2.1.2.8 | 5-fluorodeoxyuridylate |
- |
|
| 2.1.2.8 | 5-fluorodeoxyuridylate |
mechanism-based inhibitor |
|
| 2.1.2.8 | 5-hydroxymethyl-dCMP |
competitor of dCMP, inhibits formation of 5-hydroxymethyl-dCMP |
|
| 2.1.2.8 | aminopterin |
competitive inhibitor with respect to tetrahydrofolate |
|
