EC Number   |
Inhibitors |
Structure |
|---|
   2.1.1.319 | 14-benzoylacenaphtho[1',2':4,5]pyrido[2,1-b][1,3]benzothiazol-13-ium |
cell membrane permeable inhibitor that effectively blocks proliferation of cancer cells including HELA, K562, and MCF7. Prediction of the binding mode of the inhibitors by molecular docking analysis indicates that the inhibitors competitively occupy the binding site of the substrate and destroy the protein-protein interactions between CARM1 and its substrates |
   |
| 2.1.1.319 | 2-[2-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethyl]guanidine |
- |
|
| 2.1.1.319 | 4-([6-[(2H-1,3-benzodioxol-5-yl)amino]-5-nitropyrimidin-4-yl]amino)benzene-1-carboximidamide |
- |
|
| 2.1.1.319 | 4-[(6-amino-5-nitropyrimidin-4-yl)amino]benzene-1-carboximidamide |
- |
|
| 2.1.1.319 | 4-[(6-anilino-5-nitropyrimidin-4-yl)amino]benzene-1-carboximidamide |
0.05 mM, 9% inhibition |
|
| 2.1.1.319 | 4-[[5-nitro-6-(4-sulfamoylanilino)pyrimidin-4-yl]amino]benzene-1-carboximidamide |
0.05 mM, 28% inhibition |
|
| 2.1.1.319 | 4-[[6-(4-aminoanilino)-5-nitropyrimidin-4-yl]amino]benzene-1-carboximidamide |
0.05 mM, 28% inhibition |
|
| 2.1.1.319 | 4-[[6-(4-carbamimidoylanilino)-5-nitropyrimidin-4-yl]amino]benzamide |
- |
|
| 2.1.1.319 | 4-[[6-(4-cyanoanilino)-5-nitropyrimidin-4-yl]amino]benzene-1-carboximidamide |
- |
|
| 2.1.1.319 | 4-[[6-(4-hydroxy-3,5-dimethoxyanilino)-5-nitropyrimidin-4-yl]amino]benzene-1-carboximidamide |
0.05 mM, 44% inhibition |
|
