EC Number   |
Inhibitors |
Structure |
|---|
    2.1.1.17 | bezafibrate |
potent inhibitor of methylation of phosphoethanolamine |
   |
| 2.1.1.17 | Clofibric acid |
potent inhibitor of methylation of phosphoethanolamine |
|
| 2.1.1.17 | HgCl2 |
1 mM, about 90% inhibition |
|
| 2.1.1.17 | HgCl2 |
- |
|
| 2.1.1.17 | more |
phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site |
|
| 2.1.1.17 | more |
the cell toxicity for Spodoptera frugiperda (SF-9) insect cells of the phosphatidylethanolamine N-methyltransferase preparation dissapears, when the phosphatidylethanolamine N-methyltransferase preparation is treated with 100 mg Bio-Beads SM-2 + 10 mg Butyl Toyopearl or 100 g Bio-Beads SM-2 + 10 mg CM Toyopearl.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Bio-Beads SM-2 decreases the phosphatidylethanolamine N-methyltransferase activity to: 24.1% with 50 mg and 28.6% with 100 mg. Addition of 1% Trition X-100 restores the activity to 90% in the experiment with 100 mg Bio-Beads SM-2.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Butyl Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.2% with 10 mg; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent CM Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.4% with 10 mg |
|
| 2.1.1.17 | NEM |
- |
|
| 2.1.1.17 | PCMB |
1 mM, about 90% inhibition |
|
| 2.1.1.17 | PCMB |
- |
|
| 2.1.1.17 | S-adenosyl-L-homocysteine |
- |
|
