EC Number   |
Inhibitors |
Structure |
|---|
   1.8.1.B1 | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone) |
- |
   |
| 1.8.1.B1 | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone) |
- |
|
| 1.8.1.B1 | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone] |
- |
|
| 1.8.1.B1 | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone] |
- |
|
| 1.8.1.B1 | (3R,5R,8R) 5-(((3-carboxy-4-nitrophenyl)disulfanyl)methyl)tetrahydro-2H-thiazolo[4,3-b]thiazole-3-carboxylic acid |
- |
|
| 1.8.1.B1 | 1,3,4-oxadiazole-2-sulfone |
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration |
|
| 1.8.1.B1 | 1,8-naphthyridine-2 carboxylate |
mixed inhibition. 1,8-Naphthyridine-2 carboxylate prevents Tyr296 from rotating, a process necessary for NADPH binding and enzyme reduction. It inhibits by stabilizing a protein conformation whose affinity for NADPH is greatly reduced |
|
| 1.8.1.B1 | 2-((4-chlorophenyl)sulfonal)-6-methoxy-3-nitropyridine |
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. Kills schistosomes within 1 h of administration |
|
| 1.8.1.B1 | 2-(4-chlorobenzene-1-sulfonyl)-6-methoxy-3-nitropyridine |
- |
|
| 1.8.1.B1 | 2-(4-chlorophenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide |
- |
|
