EC Number |
Inhibitors |
Structure |
---|
1.5.1.6 | 5,10-dideazatetrahydrofolate |
0.4 mM, 98% inhibition, folate analog |
|
1.5.1.6 | 5-formyltetrahydrofolate |
covalent attachment completely inhibits |
|
1.5.1.6 | chymotrypsin |
cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity |
|
1.5.1.6 | hydroxylamine |
0.1 M, strong inhibition |
|
1.5.1.6 | iodoacetamide |
inhibition reversed by 2-mercaptoethanol |
|
1.5.1.6 | more |
- |
|
1.5.1.6 | more |
not inhibited by (+)-10-formyltetrahydrofolate, 5-formyltetrahydrofolate, 5-methyltetrahydrofolate, folate, aminopterin, tetrahydroaminopterin |
|
1.5.1.6 | more |
not inhibited by NADPH |
|
1.5.1.6 | more |
not inhibited by the folate analog N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]-benzoyl]-L-glutamate |
|
1.5.1.6 | more |
recombinant FDH is not inhibited by sodium azide |
|