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EC Number
Inhibitors
Commentary
Structure
1.4.1.27
2-oxo-3-methylvalerate
competitive with respect to glycine, presence leads to a decrease of apparent Km for NAD with a concomitant decrease of Vmax
1.4.1.27
2-oxoglutarate
competitive with respect to glycine, presence leads to a decrease of apparent Km for NAD with a concomitant decrease of Vmax
1.4.1.27
acetate
the presence of acetate and succinate in the growth medium results in a 50% reduction in inducible GCV enzyme activity
1.4.1.27
N-ethylmaleimide
the modification of the free lipoyl sulfhydryl group renders the intermediate complex inactive
1.4.1.27
succinate
the presence of acetate and succinate in the growth medium results in a 50% reduction in inducible GCV enzyme activity
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