EC Number   |
Inhibitors |
Structure |
|---|
   1.2.4.2 | adipoyl phosphonate |
- |
 |
| 1.2.4.2 | Co2+ |
40-50% inhibition |
  |
| 1.2.4.2 | Cu2+ |
40-50% inhibition |
|
| 1.2.4.2 | glutaryl phosphonate |
- |
|
| 1.2.4.2 | glutathione |
regulation of enzyme activity by reversible glutathionylation, inactivation with diamide |
|
| 1.2.4.2 | H2O2 |
- |
|
| 1.2.4.2 | more |
treatment of mitochondria with H2O2 or tert-butylhydroperoxide leads to decreased enzyme activity due to alterations in the glutathione status, reversible inhibition in case of H2O2, irrevrsible in case of tert-butylhydroperoxide, no direct interaction and no inhibition of isolated enzyme, inhibitory mechanism, enzyme reactivation by DTT, glutathione, and the glutaredoxin system, but not by thioredoxin system |
|
| 1.2.4.2 | more |
the thyil radical of the complex-bound lipoate inactivates E1o in the presence of 2-oxoglutarate, while thioredoxin prevents E1o inactivation |
|
| 1.2.4.2 | more |
KGDH is sharply decreased in cells challenged with menadione, treatment of cellular extracts from the menadione-exposed cells with 5 mM dithiothreitol partially restores the activity of KGDH, KGDH levels are diminished when ammonium is utilized as the nitrogen source |
|
| 1.2.4.2 | more |
no inhibition of enzyme-specific activity is observed at concentrations of 2-oxoadipate up to 8 mM |
|
