EC Number   |
Inhibitors |
Structure |
|---|
    1.2.1.24 | 2-oxoglutaric semialdehyde |
substrate inhibition |
   |
| 1.2.1.24 | 4-dimethylaminoazobenzene-4-iodoacetamide |
time-dependent loss of activity, pseudo first-order kinetics. The inhibitor binds to a cysteine residue or near its active site. Inactivation is prevented by preincubation with succinate semialdehyde, but not by preincubation with coenzyme NAD+ |
|
| 1.2.1.24 | 4-hydroxy-trans-2-nonenal |
IC50: 0.11 mM |
|
| 1.2.1.24 | 4-hydroxybenzaldehyde |
- |
|
| 1.2.1.24 | 4-hydroxybenzaldehyde |
10 mM, 82% inhibition |
|
| 1.2.1.24 | 4-hydroxybenzaldehyde |
more than 95% inhibition at 0.05 mM |
|
| 1.2.1.24 | 4-hydroxybenzaldehyde |
linear dead-end inhibition, competitive versus succinate semialdehyde, uncompetitive versus NAD+ |
|
| 1.2.1.24 | 4-methoxybenzaldehyde |
- |
|
| 1.2.1.24 | 4-tolualdehyde |
- |
|
| 1.2.1.24 | 5,5'-dithiobis(2-nitrobenzoic acid) |
0.01 mM, 66% residual activity |
|
