EC Number   |
Inhibitors |
Structure |
|---|
   1.14.13.181 | dithiothreitol |
strongly inhibitory, inhibition is reversible after desalting |
   |
| 1.14.13.181 | doxorubicin |
completely inhibits DoxA activity at both 1 and 5 mM, competitive with respect to daunorubicinol oxidation |
|
| 1.14.13.181 | more |
high ionic strength buffers containing 100 mM sodium phosphate, also strongly inhibits DoxA activity. This effect is partially reversible after exchange into low ionic strength buffers, such as 20 mM N-(2-hydroxyethyl)piperazine-N9-(2-ethanesulfonic acid) (HEPES) or 10 mM sodium phosphate (pH 7.5). No inhibition: 4-methylpyrazole (1 or 5 mM), rhodomycin D (1-5 mM) |
|
| 1.14.13.181 | quinidine |
inhibits DoxA oxidation of daunorubicinol by 11% at 1 mM. At 5 mM, it inhibits at more than 95% |
|
| 1.14.13.181 | sulfaphenazole |
inhibits DoxA oxidation of daunorubicinol by 20% at 1 mM. At 5 mM, it inhibits at more than 95% |
|
| 1.14.13.181 | troleandomycin |
inhibits DoxA oxidation of daunorubicinol by 35% at 1 mM. At 5 mM, it inhibits at more than 95% |
|
