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EC Number Inhibitors Commentary Structure
Show all pathways known for 1.1.1.318Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.318(7S,8S)-ethyl (7,8-methylene)-dihydroferulate EMDF, a mixed competitive inhibitor, chemical synthesis, and enzyme binding structure, overview. Key interactions between EMDF and the EGS holoenzyme include stacking of the phenyl ring of EMDF against the cofactor's nicotinamide ring and a water-mediated hydrogen-bonding interaction between the EMDF 4-hydroxy group and the side-chain amino moiety of a conserved lysine residue, Lys132 Go to the Ligand Summary Page
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