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Results 1 - 10 of 142 > >>
EC Number Inhibitors Commentary Structure
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol a pyrazolopyrimidine, is a potent inhibitor of the enzyme and is active against an efflux pump mutant of Escherichia coli, but cellular activity against Escherichia coli is not observed. MIC values for (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol are 0.2 mM for wild-type Escherichia coli and 0.0125 for Escherichia coli tolC mutant Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol a pyrazolopyrimidine, is a potent inhibitor of the enzyme and is active against an efflux pump mutant of Pseudomonas aeruginosa, but cellular activity against Pseudomonas aeruginosa is not observed. MIC values for (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol are over 0.2 mM for wild-type Pseudomonas aeruginosa and 0.0065 mM against the Pseudomonas aeruginosa mutant strain DELTAmexADCDXY Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol - Go to the Ligand Summary Page
Show all pathways known for 6.3.2.8Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.8(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol - Go to the Ligand Summary Page
Results 1 - 10 of 142 > >>