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EC Number
Inhibitors
Commentary
Structure
4.1.3.16
2-Ketobutyrate
competitive, Ki for 2-keto-4-hydroxybutyrate cleavage: 53 mM, Ki for 2-keto-4-hydroxyglutarate cleavage: 52 mM
4.1.3.16
2-Ketoglutarate
competitive, Ki for 2-keto-4-hydroxybutyrate cleavage: 18 mM, Ki for 2-keto-4-hydroxyglutarate cleavage: 18 mM
4.1.3.16
2-Ketoglutarate
12% inhibition at 20 mM
4.1.3.16
4-hydroxy-2-oxoglutarate
substrate inhibition, Ki: 35 mM
4.1.3.16
5,5'-dithiobis(2-nitrobenzoate)
glyoxylate and pyruvate protect
4.1.3.16
acetaldehyde
-
4.1.3.16
arsenite
-
4.1.3.16
beta-Hydroxypyruvate
-
4.1.3.16
Bromopyruvate
Ki: 0.018 mM
4.1.3.16
chloride
41% inhibition at 40 mM
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