EC Number   |
Inhibitors |
Structure  |
|---|
   3.6.1.28 | ATP |
- |
   |
| 3.6.1.28 | ATP |
1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected |
|
| 3.6.1.28 | ATP |
soluble enzyme: no inhibition up to 2 mM, membrane-bound enzyme: 50% inhibition at 5 mM |
|
| 3.6.1.28 | ATP |
very poor inhibitor |
|
| 3.6.1.28 | Mg2+ |
excess of Mg2+ over thiamine triphosphate inhibits |
|
| 3.6.1.28 | ADP |
0.001-1 mM, strong inhibition |
|
| 3.6.1.28 | ADP |
- |
|
| 3.6.1.28 | ADP |
1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected |
|
| 3.6.1.28 | Zn2+ |
0.5 mM, 59% inhibition of membrane-associated enzyme |
|
| 3.6.1.28 | Zn2+ |
inhibits at micromolar concentrations at pH 8.0, IC50: about 0.015-0.02 mM. Activates at pH 6.0 |
|
