EC Number |
Inhibitors |
Structure |
---|
3.5.3.18 | more |
not inhibited by 2-chloroacetamide |
|
3.5.3.18 | more |
incubation of lysed red blood cells with EDTA or glucose failed to attenuate the degradation of NG,NG-dimethyl-L-arginine, incubation of whole blood cells with arginine methyltransferase inhibitors does not reduce NG,NG-dimethyl-L-arginine release |
|
3.5.3.18 | more |
probucol or pyrrolidindithiocarbamate itself have no effect on the activity of DDAH |
|
3.5.3.18 | more |
5 mM of L-cysteine, L-homocysteine, glutathione, dithiothreitol, or Tris(2-carboxyethyl)phosphine-HCl for 30 min at 37°C cannot restore inhibited activity, suggesting that the covalent product N-thiosulfoximide will remain stable under the reducing conditions present in the cytosol |
|
3.5.3.18 | more |
exposure to pathophysiological levels of reactive oxygen has little to no effect on the activity of the enzyme |
|
3.5.3.18 | more |
insensitive to hydrogen peroxide |
|
3.5.3.18 | more |
tissue-specific decrease of levels of Ddah1 and Ddah2 RNA after feeding a high-methionine/low-folate diet for 5 to 11 month |
|
3.5.3.18 | more |
decrease of DDAH-2 mRNA level induced by 10% serum, ionomycin or endothelial growth factors |
|
3.5.3.18 | more |
S-ethyl-2-thiopseudourea, S-ethyl-N-phenylisothiourea and phenylene-1,3-bis(ethane-2-isothiourea) do not inhibit DDAH-1 at concentrations below 1 mM |
|
3.5.3.18 | Zn2+ |
besides the tightly bound zinc, additional Zn2+ inhibit competitively |
|