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Results 1 - 10 of 12 > >>
EC Number
Inhibitors
Commentary
Structure
1,10-phenanthroline
Zn2+ chelator
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benzyloxycarbonyl-Phe-Ala-2,4,6-trimethylbenzoyloxymethyl ketone
0.25 mM, 21% inhibition, inhibition is not reversible
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benzyloxycarbonyl-Phe-Ala-2,4,6-trimethylbenzoyloxymethyl ketone
0.25 mM, 41% inhibition, inhibition is not reversible
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benzyloxycarbonyl-Phe-Ala-2,4,6-trimethylbenzoyloxymethyl ketone
0.25 mM, 22% inhibition, inhibition is not reversible
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benzyloxycarbonyl-Phe-Lys-2,4,6-trimethylbenzoyloxymethyl ketone
0.25 mM, 76% inhibition, inhibition is not reversible
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benzyloxycarbonyl-Phe-Lys-2,4,6-trimethylbenzoyloxymethyl ketone
0.25 mM, 68% inhibition, inhibition is not reversible
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lopinavir
HIV protease inhibitors inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV protease inhibitors could play a role in the side effects of these drugs
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lovastatin
abolishes the conversion of prelamin A into lamin A
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more
HIV protease inhibitors inhibit ZMPSTE24
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o-phenanthroline
-
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Results 1 - 10 of 12 > >>