EC Number   |
Inhibitors |
Structure  |
|---|
   3.4.21.92 | more |
ClpP of E. coli has a serine and a histidine that are necessary for activity and probably represent two elements of the active site triad found in most serine proteases |
 |
| 3.4.21.92 | more |
anti-infection activity and production of hyperimmune antibodies induced by mucosal immunization with ClpP and CbpA can be abrogated by the depletion of CD4+ T lymphocytes. Hyperimmune mouse sera against ClpP and CbpA can inhibit pneumococcus adhesion to cultured A549 epithelial cells and are efficiently opsonic for uptake and killing of pneumococcus by human polymorphonuclear leukocytes in a complement-dependent assay |
|
| 3.4.21.92 | more |
not inhibitory: 4-(2-aminoethyl) benzenesulfonyl fluoride, phenylmethylsulfonyl fluoride as well as Z-L-CMK and N-p-tosylphenylalanyl chloromethyl ketone |
|
| 3.4.21.92 | Mg2+ |
proteolytic activity of ClpAP is dependent on, but concentrations higher than about 30 mM are inhibitory |
  |
| 3.4.21.92 | NEM |
- |
|
| 3.4.21.92 | NEM |
inactivates ATPase, no inhibition of peptide hydrolysis |
|
| 3.4.21.92 | diisopropyl fluorophosphate |
inhibits both oligopeptidase activity of ClpP and proteinase activity of ClpAP |
|
| 3.4.21.92 | diisopropyl fluorophosphate |
inactivates ClpP |
|
| 3.4.21.92 | diisopropyl fluorophosphate |
blocks similarly the hydrolysis of both protein and peptide substrates |
|
| 3.4.21.92 | diisopropyl fluorophosphate |
inhibitor efficiently alters the oligomerization of the enzyme to smaller species, almost quantitative shift from the tetradecamer to the heptamer with modification of 57% of the active sites |
|
