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Results 1 - 10 of 32 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92(4R)-3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one inhibitor efficiently alters the oligomerization of the enzyme to smaller species, almost quantitative shift from the tetradecamer to the heptamer with modification of 35% of the active sites Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.921-(1,1-dioxido-1,2-thiazetidin-2-yl)hexan-1-one alkyne-free beta-sultam analogue. Treatment leads to dehydroalanine formation of the active site serine. The reaction proceeds through sulfonylation and subsequent elimination, thereby obliterating the catalytic charge relay system Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.921-(4-benzoyl-1,1-dioxido-1,2-thiazetidin-2-yl)ethanone alkyne-free beta-sultam analogue. Treatment leads to dehydroalanine formation of the active site serine. The reaction proceeds through sulfonylation and subsequent elimination, thereby obliterating the catalytic charge relay system Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.921-[4-(4-ethynylbenzoyl)-1,1-dioxido-1,2-thiazetidin-2-yl]ethanone treatment results in almost instant covalent modification of all 14 active sites and complete inhibition of peptidase activity Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.921-[4-(4-ethynylbenzoyl)-1,1-dioxido-1,2-thiazetidin-2-yl]undec-10-en-1-one inhibitor efficiently alters the oligomerization of the enzyme to smaller species, almost quantitative shift from the tetradecamer to the heptamer with modification of 63% of the active sites Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.921-[4-benzoyl-1,1-dioxido-1,2-thiazetidin-2-yl]undec-10-en-1-one alkyne-free beta-sultam analogue. Treatment leads to dehydroalanine formation of the active site serine. The reaction proceeds through sulfonylation and subsequent elimination, thereby obliterating the catalytic charge relay system Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.923-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.923-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one exerts the weakest effect on peptidase activity Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.923-butyl-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92CAANDENYALAA - Go to the Ligand Summary Page
Results 1 - 10 of 32 > >>
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