EC Number |
Inhibitors |
Structure |
---|
2.8.1.6 | sinefungin |
- |
|
2.8.1.6 | Cd2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Co2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Cu2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Hg2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Zn2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | more |
5'-methylthioadenosine is not an inhibitor. Neither biotin nor iminobiotin is a significant inhibitor |
|
2.8.1.6 | Fe2+ |
above 1 mM |
|
2.8.1.6 | acidomycin |
acidomycin inhibits biotin synthesis through the competitive inhibition of biotin synthase BioB and also stimulates unproductive cleavage of S-adenosyl-L-methionine to generate the toxic metabolite 5'-deoxyadenosine. Acidomycin selectively accumulates in Mycobycterium tuberculosis. The development of spontaneous resistance by Mycobacterium tuberculosis to acidomycin is difficult, and only low-level resistance to acidomycin is observed by overexpression of BioB |
|
2.8.1.6 | S-(5'-adenosyl)-L-cysteine |
competitive |
|