Search Inhibitors

2.7.8.29

(3-sn-phosphatidyl)-L-serine

end-product inhibition of isozyme PSS1; strong end-product inhibition of isozyme PSS1

2.7.8.29

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not inhibitory: phosphatidylethanolamine, phosphatidylcholine

2.7.8.29

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addition of phosphatidylcholine instead of phosphatidylserine does not reduce the rate of phosphatidylserine synthesis

2.7.8.29

phosphatidylserine

product inhibition

2.7.8.29

phosphatidylserine

The phosphatidylserine synthesis in a CHO cell mutant which lacks PSS I, EC 2.7.8.8, but has normal PSS II activity, is almost completely inhibited by the addition of phosphatidylserine to the culture medium, like that in the wild-type CHO-K1 cells. The phosphatidylserine synthesis in a PSS II-overproducing stable transformant is reduced by 35% upon addition of phosphatidylserine. Residue Arg-97 is critical for the exogenous phosphatidylserine-mediated inhibition

2.7.8.29

phosphatidylserine

inhibition of purified enzyme and the crude enzyme in a membrane fraction