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Results 1 - 10 of 99 > >>
EC Number
Inhibitors
Commentary
Structure
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one
organotellurium inhibits creatine kinase activity by two different mechanisms: competition with ADP and oxidation of critical sulfhydryl groups for the functioning of the enzyme
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1-anilinonaphthalene-8-sulfonate
unfolding agent
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2,3-butadiene
complete inhibition, MgATP2- or MgADP- protect the enzyme from inactivation
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4,4'-dithiodipyridine
-
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4-hydroxy-2-nonenal
dose-dependent inhibition of creatine kinase, inhibition correlates with 4-hydroxy-2-nonenal adduct formation on specific amino acid residues including the active site residues H66, H191, C283, and H296
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4-hydroxy-3-nitrophenylglyoxal
complete inactivation, modification of 2 arginine residues per enzyme subunit, inhibition kinetics at pH 8.7, MgATP2- or MgADP- protect the enzyme from inactivation
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4-hydroxymercuribenzoic acid
-
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4-hydroxymercuribenzoic acid
complete inhibition at 0.01 mM
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5,5'-dithiobis(2-nitrobenzoate)
-
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5-(4-([(benzoylphenyl)amino]carbonyl)phenyl)-2-furoic acid
35% inhibition, docking energy -49.5 kcal/mol
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Results 1 - 10 of 99 > >>